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Twenty Years of The Magnificent Seven
With decades of discovery on seven transmembrane receptors, why haven't we saved the day?
Email: Thomas P Sakmar - sakmar@rockefeller.edu The Scientist 2005, 19(1):22
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To any movie buff, TM7 refers to the 1960 John Sturges movie, The Magnificent Seven, in which a 30-year-old Steve McQueen burst onto the scene fighting alongside Yul Brynner, Charles Bronson, Robert Vaughn, and James Coburn to defend the homes of an oppressed Mexican peasant village. But flip it to 7TM and it's a different allusion altogether. Nowadays every biomedical scientist knows that 7TM refers to a receptor class, the G protein-coupled receptors (GPCRs), which have taken center stage in drug discovery and the study of cellular growth and differentiation.
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